abstract：:We conducted a case-control study on fracture risk associated with the use of orally administered prednisolone/prednisone, budesonide, methylprednisolone, and hydrocortisone to assess if the various preparations were associated with different fracture patterns. Cases were all subjects with any fracture sustained durin...

journal_title：Calcified tissue international

authors： Vestergaard P,Rejnmark L,Mosekilde L

更新日期：2008-04-01 00:00:00

abstract：:The mineral in bone is located primarily within the collagen fibril, and during mineralization the fibril is formed first and then water within the fibril is replaced with mineral. Our goal is to understand the mechanism of fibril mineralization, and as a first step we recently determined the size exclusion characteri...

journal_title：Calcified tissue international

authors： Toroian D,Price PA

更新日期：2008-02-01 00:00:00

abstract：:To study the risk of fractures associated with anxiolytics, sedatives, and hypnotics, we conducted a case-control study. Cases were all subjects with any fracture during the year 2000 (n = 124,655). For each case, three controls (n = 373,962) matched on age and gender were randomly drawn from the background population...

journal_title：Calcified tissue international

authors： Vestergaard P,Rejnmark L,Mosekilde L

更新日期：2008-01-01 00:00:00

abstract：:Long chain polyunsaturated fatty acids (LCPUFAs) are involved in the regulation of bone metabolism. Increased dietary consumption of n-3, and possibly some n-6, LCPUFAs may limit postmenopausal bone loss. The aim of this study was to determine the effects on bone of specific fatty acids within the n-3 and n-6 LCPUFA f...

journal_title：Calcified tissue international

authors： Poulsen RC,Firth EC,Rogers CW,Moughan PJ,Kruger MC

更新日期：2007-12-01 00:00:00

abstract：:Newly developed fuzzy logic-derived structural parameters were used to characterize trabecular bone architecture in high-resolution magnetic resonance imaging (HR-MRI) of human cadaver calcaneus specimens. These parameters were compared to standard histomorphological structural measures and analyzed concerning perform...

journal_title：Calcified tissue international

authors： Patel PV,Eckstein F,Carballido-Gamio J,Phan C,Matsuura M,Lochmüller EM,Majumdar S,Link TM

更新日期：2007-10-01 00:00:00

abstract：:We investigated whether polymorphisms in PTHR1 are associated with bone mineral density (BMD), to determine whether the association of this gene with BMD was due to effects on attainment of peak bone mass or effects on subsequent bone loss. The PTHR1 gene, including its 14 exons, their exon-intron boundaries, and 1,50...

journal_title：Calcified tissue international

authors： Vilariño-Güell C,Miles LJ,Duncan EL,Ralston SH,Compston JE,Cooper C,Langdahl BL,Maclelland A,Pols HA,Reid DM,Uitterlinden AG,Steer CD,Tobias JH,Wass JA,Brown MA

更新日期：2007-10-01 00:00:00

abstract：:Micro-computed tomography (microCT) has become a standard tool for the evaluation of bone morphology in preclinical studies. Unfortunately, the user-dependent definition of contour lines that separate trabecular from cortical bone is not only extremely time-consuming but may also represent a source of data bias and in...

journal_title：Calcified tissue international

authors： Lublinsky S,Ozcivici E,Judex S

更新日期：2007-10-01 00:00:00

abstract：:Bone loss during advancing age in women and men is partly the result of sex steroid deficiency. As the contribution of circulating sex steroids and sex hormone-binding globulin (SHBG) to bone loss remains uncertain, we sought to determine whether levels of sex steroids or SHBG predict change in bone mineral density (B...

journal_title：Calcified tissue international

authors： Bjørnerem A,Emaus N,Berntsen GK,Joakimsen RM,Fønnebø V,Wilsgaard T,Oian P,Seeman E,Straume B

更新日期：2007-08-01 00:00:00

abstract：:Bone formation in a variety of contexts depends on angiogenesis; however, there are few reports of the vascular response to osteogenic skeletal loading. We used the rat forelimb compression model to characterize vascular changes after fatigue loading. The right forelimbs of 72 adult rats were loaded cyclically in vivo...

journal_title：Calcified tissue international

authors： Matsuzaki H,Wohl GR,Novack DV,Lynch JA,Silva MJ

更新日期：2007-06-01 00:00:00

abstract：:Acute spinal cord injury is associated with rapid bone loss and an increased risk of fracture. In this double-blind, randomized, placebo-controlled trial, 17 patients were followed for 1 year after administration of either 4 or 5 mg of zoledronic acid or placebo. Bone mineral density (BMD) and structural analyses of t...

journal_title：Calcified tissue international

authors： Shapiro J,Smith B,Beck T,Ballard P,Dapthary M,BrintzenhofeSzoc K,Caminis J

更新日期：2007-05-01 00:00:00

abstract：:The effect of long-chain n-3 polyunsaturated fatty acid (PUFA) on bone measurements was evaluated in gonad-intact middle-aged male rats. Seven rats were killed on day 0 of dietary intervention to determine bone parameters at baseline. Experimental rats (7/group) were fed one of the following lipid treatments (g/kg die...

journal_title：Calcified tissue international

authors： Shen CL,Yeh JK,Rasty J,Chyu MC,Dunn DM,Li Y,Watkins BA

更新日期：2007-04-01 00:00:00

abstract：:The CYP3A7 enzyme metabolizes some steroid hormones, including dehydroepiandrosterone sulfate (DHEAS). The age-related decline of serum DHEAS levels is believed to contribute to osteoporosis. Previously, the CYP3A7*1C polymorphism has been shown to cause a persistent high CYP3A7 enzyme activity, resulting in lower lev...

journal_title：Calcified tissue international

authors： Bácsi K,Kósa JP,Borgulya G,Balla B,Lazáry A,Nagy Z,Horváth C,Speer G,Lakatos P

更新日期：2007-03-01 00:00:00

abstract：:The aim of this study was to determine whether forearm bone mineral density (BMD) measurements are affected by clinical risk factors for osteoporosis to the same extent as spine and hip BMD. The study population consisted of 1,009 female patients and volunteers, of whom 238 were premenopausal. Women were placed into s...

journal_title：Calcified tissue international

authors： Patel R,Blake GM,Fogelman I

更新日期：2007-02-01 00:00:00

abstract：:This study aimed to evaluate the association between objectively measured habitual physical activity and calcaneal and forearm bone mineral density (BMD, g/cm(2)), one mechanically more loaded and one less loaded skeletal region, in children aged 6-8 years. BMD was measured in 297 boys and 265 girls by peripheral dual...

journal_title：Calcified tissue international

authors： Hasselstrøm H,Karlsson KM,Hansen SE,Grønfeldt V,Froberg K,Andersen LB

更新日期：2007-01-01 00:00:00

abstract：:Administration of active vitamin D sterols to treat secondary hyperparathyroidism in patients with chronic kidney disease receiving dialysis has been associated with elevated serum calcium and phosphorus levels, which may lead to increased risk of vascular calcification. However, calcimimetics, by binding to the parat...

journal_title：Calcified tissue international

authors： Shalhoub V,Shatzen E,Henley C,Boedigheimer M,McNinch J,Manoukian R,Damore M,Fitzpatrick D,Haas K,Twomey B,Kiaei P,Ward S,Lacey DL,Martin D

更新日期：2006-12-01 00:00:00

abstract：:Noncarious cervical lesions have a multifactorial etiology. Mechanical stress has been identified as one of the factors, but little evidence exists for its cause-effect relationship. This study was conducted at three different pH levels to observe the surface loss on dentin beams under tension and compression. Bovine ...

journal_title：Calcified tissue international

authors： Mishra P,Palamara JE,Tyas MJ,Burrow MF

更新日期：2006-12-01 00:00:00

abstract：:Total fat mass plays a significant role in determining bone mass, but the specific role of central adiposity independent of total fat mass has not been widely studied. Prepubertal (Tanner 1) children (n = 181; 65 boys, 116 girls, 7.8 +/- 1.5 years), including 99 Caucasians and 82 African Americans from Birmingham, Ala...

journal_title：Calcified tissue international

authors： Afghani A,Goran MI

更新日期：2006-12-01 00:00:00

abstract：:Sulfotransferase 1E1 (SULT1E1) catalyze estrogen into sulfate conjugation and is involved in the metabolism of phytoestrogen. A community-based cross-sectional study was conducted on 397 Korean women, to evaluate the association between genetic polymorphisms of SULT1E1 and bone mineral density (BMD) and the combined e...

journal_title：Calcified tissue international

authors： Lee SA,Choi JY,Shin CS,Hong YC,Chung H,Kang D

更新日期：2006-09-01 00:00:00

abstract：:The aims of this study were to compare the response to therapy in disease activity in pagetic patients with and without skull involvement and the usefulness of bone markers in the evaluation of these patients. Forty patients with Paget's disease treated with tiludronate and 26 healthy controls were included. Serum tot...

journal_title：Calcified tissue international

authors： Peris P,Alvarez L,Vidal S,Kasper D,Leeming DJ,Monegal A,Angeles Martínez M,Pons F,Guañabens N

更新日期：2006-07-01 00:00:00

abstract：:We have recently reported that soy isoflavones particularly when provided in the context of soy protein are capable of preventing loss of bone mineral density due to orchidectomy in F344 rats. We hypothesize, that soy isoflavones also exert beneficial effects on bone microstructural properties, in part, by enhancing b...

journal_title：Calcified tissue international

authors： Soung DY,Devareddy L,Khalil DA,Hooshmand S,Patade A,Lucas EA,Arjmandi BH

更新日期：2006-06-01 00:00:00

abstract：:This study sought to confirm that osteoblasts of C3H/HeJ (C3H) mice, which have higher differentiation status and bone-forming ability compared to C57BL/6J (B6) osteoblasts, also have a lower apoptosis level and to test whether the higher differentiation status and bone-forming ability of C3H osteoblasts were related ...

journal_title：Calcified tissue international

authors： Sheng MH,Lau KH,Mohan S,Baylink DJ,Wergedal JE

更新日期：2006-05-01 00:00:00

abstract：:The aim of this study was to test whether the nitric oxide (NO) donor sodium nitroprusside (SNP) has an effect on mineralization in ATDC5 cells. Mineralization in ATDC5 cell culture was induced by addition of beta-glycerophosphate or inorganic phosphate, visualized by staining precipitated calcium with an alizarin red...

journal_title：Calcified tissue international

authors： Huitema LF,Vaandrager AB,van Weeren PR,Barneveld A,Helms JB,van de Lest CH

更新日期：2006-03-01 00:00:00

abstract：:The present study was designed to characterize dentin formed in transplanted rat molars by investigating calcium (Ca), phosphorus (P), and magnesium (Mg) concentrations using electron probe microanalysis (EPMA) as well as examining the rate of dentin matrix formation by vital staining. The unerupted immature lower rig...

journal_title：Calcified tissue international

authors： Akiba N,Sasano Y,Suzuki O,Sasaki K

更新日期：2006-03-01 00:00:00

abstract：:The development of prophylaxes and treatments of bone diseases that can effectively increase the strength of bone as a structure necessitates a better understanding of the time course by which chemical properties define the stiffness of the material during primary and secondary mineralization. It was hypothesized that...

journal_title：Calcified tissue international

authors： Busa B,Miller LM,Rubin CT,Qin YX,Judex S

更新日期：2005-12-01 00:00:00

abstract：:Aging and sex hormones related changes lead to inflammatory and oxidant conditions, which are involved in the pathogenesis of osteoporosis. Recent studies have suggested that polyphenols may exert a protective effect in such conditions. We assessed the effect of phloridzin (Phlo), a flavonoid exclusively found in appl...

journal_title：Calcified tissue international

authors： Puel C,Quintin A,Mathey J,Obled C,Davicco MJ,Lebecque P,Kati-Coulibaly S,Horcajada MN,Coxam V

更新日期：2005-11-01 00:00:00

abstract：:The major transporter of vitamin D metabolites in the circulation is the multifunctional plasma protein Gc, also known as group-specific component, Gc globulin, vitamin D-binding protein, or DBP. There are several phenotypes of Gc, and we examined the influence of Gc phenotype and Gc concentration on vitamin D status....

journal_title：Calcified tissue international

authors： Lauridsen AL,Vestergaard P,Hermann AP,Brot C,Heickendorff L,Mosekilde L,Nexo E

更新日期：2005-07-01 00:00:00

abstract：:The relationship between oral indicators and bone mineral density (BMD) has been studied by many investigators, with mixed and complex results. The purpose of the present cross-sectional study was to evaluate the associations of periodontal conditions and tooth loss with metacarpal BMD (m-BMD) in a community-based coh...

journal_title：Calcified tissue international

authors： Inagaki K,Kurosu Y,Yoshinari N,Noguchi T,Krall EA,Garcia RI

更新日期：2005-07-01 00:00:00

abstract：:A case-control study was undertaken to understand the etiopathology of the bone deformities among young children in a fluoride-affected village of the Bihar State. Two villages were selected: one village with high fluoride in drinking water (7.9 +/- 4.15 ppm), and the other village with normal levels of fluoride (0.6 ...

journal_title：Calcified tissue international

authors： Khandare AL,Harikumar R,Sivakumar B

更新日期：2005-06-01 00:00:00

abstract：:Pleiotrophin (PTN) was found to have potent effects on regulation of osteoblast recruitment, proliferation and differentiation. The present study examined the long-term effects of targeted PTN over-expression on bone development and repair in a transgenic mouse model. Femurs and tibiae from the PTN transgenic mice and...

journal_title：Calcified tissue international

authors： Li G,Bunn JR,Mushipe MT,He Q,Chen X

更新日期：2005-04-01 00:00:00

abstract：:The DMS Lexxos is the first cone-beam dual X-ray absorptiometry (DXA) system capable of performing bone mineral density (BMD) measurements of the spine and hip. By using a two-dimensional (2-D) detector array rather than the linear array used with conventional fan-beam DXA systems, image acquisition time on Lexxos is ...

journal_title：Calcified tissue international

authors： Blake GM,Knapp KM,Fogelman I

更新日期：2005-02-01 00:00:00

abstract：:Mature dental enamel is the most mineralized of all mammalian tissues and considered to be free of collagen. Hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) are two nonreducible cross-links of mature collagen. Hydroxyproline (Hyp) is an amino acid that is believed to be indicative of the presence of collagen....

journal_title：Calcified tissue international

authors： Açil Y,Mobasseri AE,Warnke PH,Terheyden H,Wiltfang J,Springer I

更新日期：2005-02-01 00:00:00

abstract：:Osteoporosis is commonly associated with estrogen deficiency. However, the mechanisms by which the lack of this hormone causes bone loss are poorly understood. The bone structure of the oral cavity seems to be affected by estrogen deficiency, since a delayed healing process after tooth extraction has been observed aft...

journal_title：Calcified tissue international

authors： Zecchin KG,Pereira MC,Coletta RD,Graner E,Jorge J

更新日期：2005-02-01 00:00:00

abstract：:To compare the ability of the bone mineral density (BMD) at the distal forearm, collagen I alpha 1 (COLIA1) polymorphism, and ultrasound stiffness to identify individuals with increased risk of wrist fracture, we studied 183 postmenopausal Czech women with a wrist fracture and 178 postmenopausal controls, ages 45-70 y...

journal_title：Calcified tissue international

authors： Weichetova M,Stepan JJ,Haas T,Michalska D

更新日期：2005-02-01 00:00:00

abstract：:Undesirable changes in health-related parameters are thought to occur in retiring female athletes, but this has not been examined in longitudinal studies. The purpose of this study was to examine longitudinal changes in bone mineral density (BMD), body composition, and dietary intake in gymnasts and controls. Nonathle...

journal_title：Calcified tissue international

authors： Kudlac J,Nichols DL,Sanborn CF,DiMarco NM

更新日期：2004-12-01 00:00:00

abstract：:We have recently reported that risedronate preserves normal bone formation and decreases bone remodeling in women with postmenopausal osteoporosis after 3 years of treatment. We report now the results of a 2-year extension study. The primary objective of this study was to determine the effect of 5 years of risedronate...

journal_title：Calcified tissue international

authors： Ste-Marie LG,Sod E,Johnson T,Chines A

更新日期：2004-12-01 00:00:00

abstract：:Measurements of broadband ultrasonic attenuation (BUA) represent an established means of skeletal status assessment in osteoporosis. Today, the skeletal site that is the most widely used clinically is the calcaneus (heel bone). However, we hypothesized that fracture risk predictions could be improved if ultrasound mea...

journal_title：Calcified tissue international

authors： Padilla F,Akrout L,Kolta S,Latremouille C,Roux C,Laugier P

更新日期：2004-11-01 00:00:00

abstract：:The purpose of this study was to (1) quantify the healing process of the human osteoporotic proximal humerus fracture (PHF) expressed in terms of callus formation over the fracture region using BMD scanning, and (2) quantify the impact of medical intervention with vitamin D3 and calcium on the healing process of the h...

journal_title：Calcified tissue international

authors： Doetsch AM,Faber J,Lynnerup N,Wätjen I,Bliddal H,Danneskiold-Samsøe B

更新日期：2004-09-01 00:00:00

abstract：:Hepatitis C treatment with interferon alpha-2b (IFN-alpha) and ribavirin has been related to decreased bone mineral density. The aim of this study was to investigate the in vitro effects of different concentrations of ribavirin and IFN-alpha on osteoblast-like cells. Human osteoblast-like cells obtained by the outgrow...

journal_title：Calcified tissue international

authors： Moreira RO,Balduíno A,Martins HS,Reis JS,Duarte ME,Farias ML,Borojevic R

更新日期：2004-08-01 00:00:00

abstract：:A positional cloning effort in French Canadian families with Paget's disease of bone (PDB) resulted in the identification of a mutation in the sequestosome1 (SQSTM1) gene in a subset of both familial and sporadic PDB cases. This was confirmed in samples of mainly United Kingdom (UK) origin. In this study, we performed...

journal_title：Calcified tissue international

authors： Beyens G,Van Hul E,Van Driessche K,Fransen E,Devogelaer JP,Vanhoenacker F,Van Offel J,Verbruggen L,De Clerck L,Westhovens R,Van Hul W

更新日期：2004-08-01 00:00:00

abstract：:The interaction between estrogens and androgens, with their protective effects in bone, and parathyroid hormone (PTH), a calcitropic peptide hormone, is complex but may be better understood with murine models. The purpose of this study was to characterize skeletal phenotypes of mice deficient in estrogen receptor alph...

journal_title：Calcified tissue international

authors： Tözüm TF,Oppenlander ME,Koh-Paige AJ,Robins DM,McCauley LK

更新日期：2004-07-01 00:00:00